Table 9 An assessment of the changes in urine sediments affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Tests		Result	Severity	Groups (mg/kg/day)a)
				Male							Female
				G1%		G2	G3		G4		G1	G2		G3	G4
RBC		-	0	4		5	5		5		5	5		5	5
		+/－	1	1
WBC		-	0	5		5	5		5		5	5		5	5
Epithelial cell		-	0	3		4	4		4		4	3		5	4
		+/－	1	2		1	1		1		1	2			1
Casts		-	0	4		4	4		5		4	4		3	4
		+/－	1	1		1	1				1	1		2	1
No. of animals				5		5	5		5		5	5		5	5
" "= no finding, %: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)
Grade	RBC (mean/field)				WBC (mean/field)			Epithelial cell					Casts (mean/field)
-	0				0			0 / 20 fields					0
+/－	≤4				≤5			Few / 20 fields					1
1+	5~8				6~20			Around 1 / few field					2~5