Table 8 An assessment of the urinalysis changes affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)
| Tests | Result | Severity | Groups (mg/kg/day) |
| Male | | Female |
| G1% | G2 | G3 | G4 | | G1 | G2 | G3 | G4 |
| 0 | 1,250 | 2,500 | 5,000 | | 0 | 1,250 | 2,500 | 5,000 |
| GLU | - | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| BIL | - | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| KET | - | 0 | 4 | 2 | | | 5 | 5 | 5 | 5 |
| +/－ | 1 | | 1 | | 2 | | | | |
| 1+ | 2 | 1 | 2 | 5 | 3 | | | | |
| SG | ≤1.005 | 0 | | | | | 1 | | | |
| 1.010 | 1 | 4 | 2 | | 1 | 1 | 4 | 3 | |
| 1.015 | 2 | 1 | 2 | 4 | 3 | | | | 4 |
| 1.020 | 3 | | 1 | 1 | 1 | 3 | 1 | 2 | 1 |
| pH | ≤6.5 | 0 | | | | | 1 | | | |
| 7.0 | 1 | | | | | | | 1 | |
| 7.5 | 2 | | | | | 1 | | 2 | 1 |
| 8.0 | 3 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 2 |
| 8.5 | 4 | 4 | 4 | 3 | 2 | 2 | 4 | 1 | 2 |
| PRO | - | 0 | 2 | | | | 3 | 4 | 3 | |
| +/－ | 1 | 1 | | | 1 | 2 | 1 | 1 | 3 |
| 1+ | 2 | 2 | 4 | 3 | 1 | | | | 2 |
| 2+ | 3 | | 1 | 1 | 3 | | | 1 | |
| 3+ | 4 | | | 1 | | | | | |
| UROa) | 0.2 | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 3 |
| 1 | 1 | | | | | | | | 2 |
| NIT | - | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| OB | - | 0 | 2 | 2 | 5 | 5 | 5 | 5 | 4 | 5 |
| +/－ | 1 | 3 | 2 | | | | | | |
| 1+ | 2 | | 1 | | | | | | |
| 2+ | 3 | | | | | | | 1 | |
| LEU | - | 0 | 2 | | | 1 | 4 | 5 | 4 | 4 |
| +/－ | 1 | 1 | 3 | 1 | | 1 | | | 1 |
| 1+ | 2 | 1 | 2 | 3 | 2 | | | 1 | |
| 2+ | 3 | 1 | | | 2 | | | | |
| 3+ | 4 | | | 1 | | | | | |
| No. of animals | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
a) The unit of Urobilinogen is Ehrlich unit/dL, * Represents a significant difference at p<0.05 level compared with the vehicle control, %: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day), The data shown represent mean±S.D. (n=10), GLU: Glucose, BIL: Bilirubin, KET: Ketone body, SG: Specific gravity, PRO: Protein, URO: Urobilinogen, NIT: Nitrite, OB: Occult blood, LEU: Leukocyte