Table 5 Weekly investigation results of the effects on the body weight changes during the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Weeks	Groups (mg/kg/day)^b)
	G1^%		G2		G3		G4
	Male	Female	Male	Female	Male	Female	Male	Female
0	192.2± 5.46	155.1± 7.00	191.3± 6.42	153.8± 4.71	190.4± 7.92	153.6± 6.47	191.2± 5.05	152.2± 9.99
1	248.8±11.93	174.0±11.36	249.2± 9.26	171.8±11.24	244.9±12.22	171.8± 9.05	248.3± 9.26	172.9±12.00
2	303.6±17.49	194.5±15.46	302.3±11.12	186.6±7.28	297.1±18.25	189.0± 7.08	300.0±13.58	193.1±12.05
3	348.9±23.49	211.0±14.11	346.2±14.88	202.3±10.75	336.7±23.12	206.3±10.48	339.3±18.00	211.0±12.09
4	386.3±30.30	223.5±12.21	380.4±17.54	215.2±9.40	368.9±26.04	219.4±11.90	369.4±22.63	228.0±11.19
5	418.0±34.94	238.8±16.96	412.0±21.18	224.2±8.56	395.9±29.46	230.5±12.09	397.7±22.87	237.6±12.91
6	441.6±40.03	248.5±15.74	436.9±23.61	234.9±11.48	419.3±34.58	239.0±11.83	421.1±23.72	243.7±17.51
7	461.8±45.67	257.4±18.26	455.8±24.05	244.7±12.94	439.9±38.17	246.3± 9.03	441.2±21.67	255.3±14.88
8	481.3±49.84	268.6±16.75	475.2±25.78	249.5±12.84	455.1±40.38	254.0±12.17	458.3±21.57	264.7±16.73
9	497.0±53.12	276.5±21.71	494.5±28.63	253.0±11.56	472.6±43.81	259.7±12.16	472.3±20.01	267.6±15.26
10	511.6±56.97	277.3±19.02	509.8±31.12	255.8±11.47	488.4±47.95	263.8±12.80	486.3±22.67	269.8±16.88
11	523.2±59.13	282.0±19.73	521.9±33.53	263.0±13.51	501.8±53.11	268.2± 8.32	497.5±24.40	277.8±17.34
12	538.3±60.81	288.7±19.99	539.3±37.42	269.7±16.83	515.6±56.08	271.7±11.61	512.1±23.62	286.0±18.24
13	538.7±62.09	295.3±24.87	541.6±37.64	272.5±17.62	517.8±59.78	276.8± 9.83	513.1±23.61	287.0±17.25
Gains^a)	346.5±60.02	140.2±21.30	350.3±34.53	118.6±14.55	327.4±53.78	123.1± 9.04	321.8±21.62	134.8±16.20

^a) Weight gains are body weight difference between week 13 and week 0.
%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)
The data shown represent mean±S.D. (n=10).