| Weight-based classification | Male | Female | |||
|---|---|---|---|---|---|
| Finding | Dose(mg/kg/day) | Finding | Dose(mg/kg/day) | ||
| Important compound-related changes | Not detected | Not detected | |||
| Minour compound-related changes | Weigh of organ (kidney, increase) | 5,000 | Food consumption decrease | 5,000 | |
| Weight of organ (kidney increase) | 5,000 | ||||
| Weight of organ (thymus, decrease) | 5,000 | ||||
| Histological examination (kidney, glomerulosclerosis) | 0, 5,000 | ||||
| Noncompound-related changes | Urinalysis (PRO, increase) | 1,250 | Blood chemistry (Ca2+ decrease) | 1,250, 2,500 | |
| Urinalysis (KET, SG increase) | 2,500 | Diagnosis of autopsy (redness of thymus) | 2,500, 5,000 | ||
| Histological examination (testis, dwarf) | 1,250 | Diagnosis of autopsy (retention of clearfluid in uterus) | 0, 1,250, 2,500, 5,000 | ||
| Histological examination (bortyoid tumor of rib) | 1,250 | Diagnosis of autopsy (retention of clearfluid in ovary) | 0 | ||
| Diagnosis of autopsy (redness of lung) | 0, 1,250, 2,500, 5,000 | ||||
| Histological examination (glomerulosclerosis of kidney) | 0, 5,000 | Histological examination (kidney, inflammatory cellular infiltration) | 0 | ||
| Histological examination (inflammatory cell infiltration of kidney) | 0, 5,000 | Histological examination (cytothesis of kidney) | 0, 5,000 | ||
| Histological examination (kidney tissue regeneration) | 0, 5,000 | Histological examination (kidney remain cool minereol) | 0, 5,000 | ||
| Histological examination (hepatocyte vacuolation) | 5,000 | Histological examination (cystitis Jeungsepojimyun) | 0 | ||
| Histological examination (heart myocarditis) | 0 | Histological examination (liver, focal necrosis) | 0 | ||
| Histological examination (spleen, hemosiderin pigment) | 5,000 | ||||