Table 17 An assessment of the changes in histopathological findings affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Organs	Observed signs	Groups (mg/kg/day)a)
		G1%			G2			G3			G4
		Male	Female		Male	Female		Male	Female		Male	Female
Kidney	Glomerulosclerosis	3	1								2	3
	Inflammatory cells infiltration	3	2								1	-
	Regeneration	2	1								1	1
	Mineralization		1									1
Liver	Vacuolization of hepatocytes	-	1								1	-
Urinary bladder	Inflammatory cells infiltration		1									-
Heart	Myocarditis	1									-
Spleen	Hemosiderin pigment		-									1
No. of animals		10	10								10	10

" - "=no finding , “ ”= no slide
%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day)