Table 16 An assessment of the changes in necropsy findings affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Organs	Observed signs	Groups (mg/kg/day)a)
		G1%*			G2			G3			G4
		Male	Female		Male	Female		Male	Female		Male	Female
Testis	Undersized	0			1			0			0
Rib	Tumor	0			1			0			0
Uterus	Retention of clear fluid		1			1			1			1
Ovary	Retention of red fluid		1			0			0			0
Lung	Redness		2			2			4			2
Thymus	Redness		0			0			1			1
No. of animals		10	10		10	10		10	10		10	10

%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day)
^* Represents a significant difference at p<0.05 level compared with the vehicle control.