Table 15 An assessment of the changes in relative organ weights (% of body weight) affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Organ weight(g)#	Groups (mg/kg/day)a)
	G1%*			G2			G3			G4
	Male	Female		Male	Female		Male	Female		Male	Female
Adrenal(L)	0.0050±0.00053	0.0229±0.00380		0.0047±0.00055	0.0237±0.00415		0.0052±0.00077	0.0229±0.00286		0.0052±0.00056	0.0244±0.00374
Adrenal(R)	0.0047±0.00074	0.0234±0.00428		0.0047±0.00037	0.0255±0.00465		0.0049±0.00053	0.0241±0.00465		0.0052±0.00050	0.0252±0.00373
Pituitary	0.0026±0.00021	0.0113±0.00163		0.0024±0.00024	0.0124±0.00128		0.0026±0.00031	0.0123±0.00196		0.0026±0.00034	0.0124±0.00180
Thymus	0.0880±0.01341	0.1122±0.02049		0.0864±0.02290	0.0941±0.01688		0.0880±0.01989	0.0963±0.01479		0.0877±0.01314	0.0875±0.01979
Ovary(L)		0.0110±0.00145			0.0115±0.00097			0.0117±0.00130			0.0118±0.00170
Ovary(R)		0.0059±0.00097			0.0061±0.00078			0.0066±0.00084			0.0067±0.00050
Prostate	0.1448±0.02427			0.1513±0.02024			0.1296±0.02875			0.1432±0.02411
Testis(L)	0.3779±0.04179			0.3583±0.03393			0.3740±0.03992			0.3865±0.03005
Testis(R)	0.3841±0.03758			0.3340±0.06588			0.3742±0.03695			0.3882±0.03307
Epididymis(L)	0.1323±0.01261			0.1307±0.01507			0.1334±0.01453			0.1383±0.00861
Epididymis(R)	0.1354±0.01291			0.1249±0.01929			0.1381±0.01308			0.1419±0.00831
Spleen	0.2061±0.04519	0.2110±0.02591		0.2143±0.03298	0.2239±0.02055		0.2271±0.06144	0.2186±0.03265		0.1956±0.03444	0.2183±0.03465
Kidney(L)	0.2741±0.01348	0.2891±0.03081		0.2711±0.02207	0.3063±0.02508		0.2862±0.02674	0.2949±0.01793		0.3094±0.02196*	0.3185±0.02325*
Kidney(R)	0.2754±0.02132	0.2907±0.02340		0.2788±0.02398	0.3031±0.03198		0.2899±0.02872	0.3039±0.01906		0.3102±0.02247*	0.3167±0.01676*
Heart	0.2754±0.01906	0.3121±0.02798		0.2722±0.01623	0.3264±0.03347		0.2787±0.02187	0.3208±0.02791		0.2840±0.02408	0.3143±0.01968
Lung	0.3564±0.03426	0.4531±0.03020		0.3377±0.03376	0.4959±0.03694		0.3567±0.03688	0.4827±0.02846		0.3629±0.02254	0.4780±0.03868
Brain	0.4359±0.04430	0.7295±0.07218		0.4264±0.03163	0.7715±0.05495		0.4427±0.04191	0.7625±0.03782		0.4461±0.02088	0.7443±0.06426
Liver	2.6702±0.18633	2.4282±0.36368		2.6330±0.10828	2.4762±0.28171		2.6862±0.22023	2.4762±0.17913		2.7435±0.19710	2.5284±0.16711
No. of animals	10	10		10	10		10	10		10	10

The data shown represent means±S.D. (n=10), %: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), ^* Represents a significant difference at p<0.05 level compared with the vehicle control, ^# Ratio (%); Relative ratio of organ weight against body weight