Table 14 An assessment of the changes in absolute organ weights affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Organ weight#(g)	Groups (mg/kg/day)a)
	G1%*			G2			G3			G4
	Male	Female		Male	Female		Male	Female		Male	Female
Adrenal(L)	0.0260±0.00294	0.0634±0.01079		0.0243±0.00242	0.0609±0.00845		0.0256±0.00303	0.0602±0.00714		0.0259±0.00310	0.0655±0.00816
Adrenal(R)	0.0244±0.00347	0.0647±0.01186		0.0243±0.00202	0.0654±0.01014		0.0243±0.00237	0.0634±0.01206		0.0257±0.00275	0.0683±0.01172
Pituitary	0.0133±0.00161			0.0124±0.00141			0.0130±0.00154			0.0129±0.00174
Thymus	0.4588±0.09823	0.3136±0.06780		0.4471±0.10037	0.2451±0.05655		0.4425±0.13683	0.2520±0.03107		0.4321±0.06935	0.2344±0.04380*
Pituitary		0.0312±0.00446			0.0319±0.00308			0.0324±0.00561			0.0334±0.00489
Ovary(L)		0.0304±0.00361			0.0297±0.00330			0.0307±0.00416			0.0319±0.00412
Ovary(R)		0.0163±0.00253			0.0158±0.00176			0.0173±0.00218			0.0180±0.00131
Prostate	0.7492±0.15138			0.7916±0.12675			0.6470±0.15774			0.7047±0.11978
Testis(L)	1.9440±0.16247			1.8693±0.18969			1.8509±0.16331			1.9046±0.18961
Testis(R)	1.9791±0.18432			1.7446±0.35818			1.8530±0.15628			1.9120±0.19394
Epididymis(L)	0.6816±0.05997			0.6816±0.07728			0.6609±0.06245			0.6812±0.05264
Epididymis(R)	0.6975±0.05698			0.6495±0.08645			0.6848±0.06111			0.6982±0.04752
Spleen	1.0666±0.24859	0.5887±0.10268		1.1236±0.21456	0.5799±0.07361		1.1258±0.30077	0.5730±0.07541		0.9650±0.18379	0.5903±0.10374
Kidney(L)	1.4185±0.14116	0.7994±0.06339		1.4113±0.08042	0.7903±0.06262		1.4211±0.15464	0.7757±0.06449		1.5246±0.13816	0.8581±0.04814
Kidney(R)	1.4209±0.12167	0.8044±0.04636		1.4522±0.09971	0.7817±0.07460		1.4361±0.13310	0.7986±0.05700		1.5268±0.12167	0.8541±0.04648
Heart	1.4230±0.13770	0.8644±0.06959		1.4238±0.15498	0.8420±0.08140		1.3826±0.10954	0.8429±0.07471		1.3981±0.12799	0.8480±0.06259
Lung	1.8385±0.19198	1.2578±0.11501		1.7574±0.14490	1.2794±0.08861		1.7622±0.07097	1.2682±0.08068		1.7882±0.15544	1.2864±0.06129
Brain	2.2381±0.07477	2.0151±0.10113		2.2191±0.07777	1.9880±0.08094		2.1878±0.08788	2.0035±0.11266		2.1944±0.09831	2.0017±0.07320
Liver	13.8765±1.99662	6.7533±1.17137		13.7635±1.21293	6.3858±0.68144		13.4108±1.90139	6.5099±0.54514		13.5237±1.33087	6.8268±0.56704
No. of animals	10	10		10	10		10	10		10	10

The data shown represent means±S.D. (n=10).
%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day)
^* Represents a significant difference at p<0.05 level compared with the vehicle control.
^# Weight (g); unit of absolute weight of organ