Table 11 An assessment of the changes in hematological values affected by the 90-day oral administration of 7%-GNANA, a test substance to the male and female rats (n=10)

Tests	Units	Groups (mg/kg/day)
		G1			G2			G3			G4
		Male	Female		Male	Female		Male	Female		Male	Female
WBC	103/μL	3.97±0.884	2.03±0.813		4.03±0.750	1.72±0.787		3.71±1.148	1.73±0.689		3.72±0.701	1.82±0.621
RBC	106/μL	9.03±0.282	8.26±0.405		9.44±0.510	8.32±0.407		9.20±0.481	8.34±0.462		9.27±0.498	8.31±0.358
HGB	g/dL	13.9±0.79	13.8±0.65		13.8±0.82	14.0±0.29		13.4±1.38	13.8±0.39		14.1±0.54	13.8±0.47
HCT	%	44.2±1.56	43.1±2.01		44.6±1.72	43.3±0.73		44.5±1.73	42.9±1.13		44.7±1.21	42.7±1.10
MCV	fL	49.0±2.56	52.2±1.15		47.3±2.58	52.1±2.07		48.4±2.53	51.6±2.24		48.3±2.22	51.4±2.13
MCH	pg	15.4±1.13	16.8±0.53		14.7±1.26	16.8±0.86		14.5±1.48	16.6±0.90		15.2±1.12	16.6±0.91
MCHC	g/dL	31.4±1.13	32.2±0.44		31.0±1.00	32.3±0.50		30.0±2.58	32.1±0.43		31.4±0.90	32.3±0.54
RDW	%	13.4±0.94	11.6±1.07		13.4±0.96	11.6±1.20		13.2±0.77	12.0±1.40		13.1±0.66	12.0±1.34
HDW	g/dL	3.26±0.450	2.80±0.408		3.42±0.426	2.83±0.346		3.35±0.460	2.90±0.461		3.35±0.464	2.91±0.477
PLT	103/μL	1,075±252.3	977±104.1		1,112±82.9	881±308.3		1,076±187.3	1,038±132.2		1,027±86.3	1,040±112.0
MPV	fL	7.6±0.28	7.7±0.43		7.7±0.50	8.0±1.04		7.7±0.37	7.9±0.52		7.6±0.36	7.7±0.30
RET	%	1.93±0.526	1.86±0.375		2.04±0.553	1.84±0.542		1.96±0.440	1.95±0.422		1.70±0.250	1.88±0.340
NEU	%	26.7±9.62	21.0±3.91		25.0±4.08	20.4±7.13		26.6±5.79	23.0±6.25		27.4±7.72	20.9±6.48
	103/μL	1.05±0.451	0.44±0.223		1.01±0.273	0.35±0.175		0.99±0.376	0.40±0.204		1.00±0.265	0.37±0.166
LYM	%	68.2±10.15	73.3±3.33		68.9±4.07	73.9±6.81		67.6±5.83	71.5±7.01		66.9±8.22	73.6±6.47
	103/μL	2.71±0.690	1.48±0.576		2.77±0.506	1.28±0.664		2.49±0.795	1.24±0.499		2.50±0.607	1.35±0.481
MONO	%	2.5±0.53	2.3±0.96		3.1±0.52	2.1±0.61		3.0±0.81	2.1±0.55		2.9±0.62	2.2±0.46
EOS	%	2.1±0.36	2.9±0.98		2.3±0.54	2.7±1.21		2.2±0.71	2.8±1.02		2.3±0.84	2.8±0.88
BASO	%	0.1±0.06	0.1±0.11		0.1±0.05	0.3±0.26		0.1±0.07	0.2±0.14		0.0±0.05	0.1±0.09
LUC	%	0.5±0.27	0.3±0.19		0.8±0.29	0.5±0.31		0.6±0.37	0.4±0.23		0.4±0.18	0.4±0.13
No. of animals		10	10		10	10		10	10		10	10

WBC (White blood cell count), RBC (Red blood cell count), HGB (Hemoglobin conc.), HCT (Hematocrit), MCV (Mean corpuscular volume), MCH (Mean corpuscular hemoglobin), MCHC (Mean corpuscular Hb conc.), RDW (Red cell distribution width), HDW (Hb conc. distribution width), PLT (Platelet), MPV (Mean platelet volume), RET (Reticulocyte)