Table 9 An assessment of the changes in urine sediments affected by the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10)

Tests	Result		Severity	Groups (mg/kg/day)^a)
				Male						Female
				G1^%		G2	G3	G4		G1	G2		G3	G4
				0		1,250	2,500	5,000		0	1,250		2,500	5,000
RBC	-		0	^4*		4	4	5		5^*	5		5	5
RBC	+/－		1	1^*		1	1
WBC	-		0	5^*		5	4	5		5^*	5		5	5
Epithelial cell	+/－		1				1
Epithelial cell	-		0	5^*		5	5	5		5^*	5		5	5
Casts	-		0	2^*		1	3	4		4^*	5		5	4
Casts	+/－		1	3^*		4	2	1		1^*				1
No. of animals				5		5	5	5		5	5		5	5
" "= no finding ^*: Represents a significant difference at p <0.05 level compared with the vehicle control. %: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)
Grade		RBC (mean/field)			WBC (mean/field)				Epithelial cell			Casts (mean/field)
-		0			0				0 / 20 fields			0
+/－		≤4			≤5				Few / 20 fields			1
1+		5~8			6~20				Around 1 / few field			2~5