Table 4 Investigation results of clinical signs through the autopsy after the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10)

Days	Signs	Groups (mg/kg/day)^b)
		G1 (0)^%		G2 (1,250)		G3 (2,500)		G4 (5,000)
		Male	Female	Male	Female	Male	Female	Male	Female
0	No finding	0 / 10^a)*	0 / 10a)^*	0 / 10^a)	0 / 10^a)	0 / 10^a)	0 / 10^a)	0 / 10^a)	0 / 10^a)
1~7	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
8~14	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
15~21	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
22~28	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
29~35	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
36~42	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
43~49	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
50~56	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
57~63	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
64~70	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
71~77	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
78~84	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
85~91	No finding	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10	0 / 10
91	Terminal sacrifice	10 / 10	10 / 10	10 / 10	10 / 10	10 / 10	10 / 10	10 / 10	10 / 10

^a) Number of animals with the sign / Number of animals examined.
^*: Represents a significant difference at p<0.05 level compared with the vehicle control
%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)