| Weight-based classification | Finding | Dose(mg/kg/day) |
|---|---|---|
| Important compound-related changes | Not detected | |
| Minour compound-related changes | Absolute weight of organ (kidney) | 5,000 |
| Body weight | 5,000 | |
| Food consumption decrease | 5,000 | |
| Noncompound-related changes | Urinalysis (PRO, LEU) | 5,000 |
| Hematological values (HDW) | 2,500 | |
| Serum biochemical values (ALB) | 5,000 | |
| Necropsy findings (right adrenal, atropy) | 5,000 | |
| Necropsy findings (uterus) | 5,000 | |
| Histological examination of organ (kidney: protein casts) | 0(4/10), 1,250(2/10), 2,500(2/10), 5,000(2/10) | |
| Histological examination of organ (kidney: mineralization) | 0(1/10), 1,250(7/10), 2,500(6/10), 5,000(1/10) | |
| Histological examination of organ (kidney: vacuolation) | 0(1/10), 5,000(1/10) |