Table 17 An assessment of the changes in histopathological findings affected by the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10)

Organs	Observed signs	Male groups (mg/kg/day)
		G1 (0)%	G2 (1,250)	G3 (2,500)	G4 (5,000)
Testis	Atropy degeneration	-			1
Prostate	Inflammatory cells infiltration	2			1
Kidney	Protein casts	5	2	4	6
Liver	Bile duct hyperplasia	1			-
Lung	Osseous metaplasia	-			1
Heart	Focal myocarditis	2			1
Stomach	Ulcer of the glandular stomach	1			-
No. of animals		10	10	10	10
" - "=no finding , “ ”= no slide
Organs	Observed signs	Female groups (mg/kg/day)
		G1 (0)	G2 (1,250)	G3 (2,500)	G4 (5,000)
Pituitary gland	Cyst in pars distalis	1			-
Kidney	Protein casts	4	2	2	2
	Mineralization	1	7	6	1
Liver	Vacuolization of hepatocytes	2			2
No. of animals		10	10	10	10

%: Control group (G1), Low-dose group (G2: 1,250 mg/10mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)