Table 14 An assessment of the changes in absolute organ weights affected by the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10)

Organ weight(g)**	Groups (mg/kg/day)a)
	G1 (0)%		G2 (1,250)		G3 (2,500)		G4 (5,000)
	Male	Female	Male	Female	Male	Female	Male	Female
Adrenal(L)	0.0273±0.00330#	0.0398±0.00213	0.0269±0.00282	0.0386±0.00492	0.0266±0.00562	0.0397±0.00718	0.0272±0.00424	0.0372±0.00482
Adrenal(R)	0.0259±0.00336	0.0392±0.00542	0.0263±0.00440	0.0408±0.00456	0.0255±0.00397	0.0392±0.00661	0.0261±0.00456	0.0333±0.01054
Pituitary	0.0130±0.00174	0.0165±0.0326	0.0143±0.00189	0.0182±0.00325	0.0139±0.00157	0.0163±0.00206	0.0143±0.00190	0.0167±0.00218
Thymus	0.4569±0.08093	0.3370±0.10573	0.5105±0.18627	0.3872±0.09727	0.4871±0.10775	0.3435±0.09169	0.4909±0.10473	0.3074±0.03914
Ovary(L)		0.0688±0.01771		0.0780±0.01468		0.0715±0.01331		0.0737±0.01449
Ovary(R)		0.0673±0.00615		0.0764±0.01492		0.0754±0.01141		0.0693±0.00932
Prostate	0.6315±0.16339		0.6204±0.15144		0.6155±0.14804		0.5403±0.14546
Testis(L)	1.8639±0.20540		1.9584±0.15974		1.7444±0.17545*		1.8240±0.17074
Testis(R)	1.8120±0.14054		1.9679±0.11373		1.7764±0.17716		1.7498±0.35661
Epididymis(L)	0.6863±0.03698		0.7116±0.09057		0.6431±0.05631		0.6816±0.06143
Epididymis(R)	0.6731±0.04870		0.6982±0.05782		0.6639±0.08136		0.6498±0.10270
Spleen	0.9194±0.08364	0.6297±0.07729	0.9994±0.16638	0.6790±0.08400	1.0320±0.13502	0.6413±0.08946	1.0008±0.12714	0.6498±0.07385
Kidney(L)	1.4725±0.11574	0.8769±0.07588	1.5403±0.15726	0.9061±0.11011	1.6328±0.14390	0.9367±0.06745	1.6871±0.12453*	0.9664±0.06190*
Kidney(R)	1.4922±0.11461	0.9028±0.07541	1.5300±0.17386	0.9351±0.10183	1.6126±0.16372	0.9415±0.09486	1.7091±0.15882*	0.9592±0.06163*
Heart	1.4217±0.12557	0.9516±0.11100	1.4918±0.13270	0.9804±0.10498	1.4916±0.06865	0.9969±0.10816	1.4854±0.15590	0.9284±0.06195
Lung	1.6958±0.16983	1.2930±0.07141	1.8385±0.18201	1.3479±0.11882	1.8472±0.20741	1.3290±0.12040	1.7812±0.13207	1.2547±0.06234
Brain	2.1491±0.07594	1.9802±0.08832	2.1776±0.06963	2.0075±0.08400	2.1359±0.11050	2.0020±0.07200	2.1519±0.15218	1.9543±0.06489
Liver	12.3151±1.23092	7.0642±0.90601	13.5804±1.56510	7.4692±0.74168	13.1876±1.38006	7.2520±1.15298	13.5080±1.31425	6.9651±0.54964
No. of animals	10	10	10	10	10	10	10	10

^*: Represents a significant difference at p<0.05 level compared with the vehicle control.
^**: Weight (g): unit of absolute weight of organ%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)
^#: The data shown represent means ± S.D. (n=10).