Table 13 An assessment of the changes in plasma coagulation values affected by the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10

Tests	Groups (mg/kg/day)a)
	G1 (0)%		G2 (1,250)		G3 (2,500)		G4 (5,000)
	Male	Female	Male	Female	Male	Female	Male	Female
PT(sec)	10.30±0.461#	9.11±0.425*	9.52±0.546*	8.99±0.409	9.67±0.709	9.14±0.694	9.42±1.074	8.81±0.394
APTT(sec)	18.10±1.073	16.64±0.703*	18.36±1.645	16.78±1.266	17.80±1.733	17.50±1.121	18.85±0.908	17.13±1.365
No. of animals	10	10	10	10	10	10	10	10

^*: Represents a significant difference at p<0.05 level compared with the vehicle control
%: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)
^#: The data shown represent means±S.D. (n=10)