Table 11 An assessment of the changes in hematological values affected by the 90-day oral administration of 23%-GNANA, a test substance to the male and female rats (n=10)

Tests**	Units	Groups (mg/kg/day)
		G1 (0)%		G2 (1,250)			G3 (2,500)		G4 (5,000)
		Male	Female	Male	Female		Male	Female	Male	Female
WBC	103/μL	3.87±1.392#	1.57±0.501	3.88±1.060	1.92±0.664		3.77±0.837	1.62±0.382	3.59±0.968	1.98±0.871
RBC	106/μL	8.94±0.231	7.89±0.311	8.66±0.253*	7.97±0.315		8.75±0.285	7.96±0.348	8.71±0.241	7.92±0.305
HGB	g/dL	15.55±0.378	14.60±0.506	15.49±0.448	14.88±0.326		15.35±0.455	14.78±0.630	15.27±0.343	14.72±0.442
HCT	%	47.07±1.117	43.36±1.089	46.44±1.551	43.96±1.177		46.22±1.167	44.02±1.532	46.20±1.112	44.31±1.215
MCV	fL	52.70±1.815	55.03±1.650	53.62±1.673	55.21±1.523		52.85±1.189	55.30±1.333	53.07±1.487	56.00±1.988
MCH	pg	17.44±0.688	18.52±0.725	17.88±0.531	18.67±0.566		17.54±0.508	18.54±0.544	17.54±0.499	18.61±0.854
MCHC	g/dL	33.08±0.525	33.67±0.673	33.33±0.462	33.86±0.467		33.18±0.406	33.53±0.706	33.04±0.324	33.21±0.762
RDW	%	12.45±0.477	10.93±0.306	12.17±0.430	10.98±0.382		12.37±0.406	11.25±0.528	12.30±0.503	11.12±0.382
HDW	g/dL	2.67±0.171	2.41±0.072	2.61±0.080	2.46±0.084		2.65±0.143	2.52±0.098*	2.66±0.109	2.44±0.090
PLT	103/μL	1,052±109	1,097±161	1,037±118	1,051±111		1,069.40±113	1,122±131	1,032±98	1,1300±159
MPV	fL	8.25±0.350	8.20±0.371	8.27±0.236	8.10±0.271		8.42±0.459	8.02±0.442	8.27±0.327	8.30±0.508
RET	%	1.46±0.195	1.53±0.409	1.57±0.249	1.68±0.394		1.59±0.194	1.77±0.431	1.65±0.199	1.86±0.382
NEU	%	18.60±8.957	18.50±10.137	17.63±8.236	16.31±7.734		15.02±4.128	18.96±8.410	14.79±5.314	13.38±4.041
	103/μL	0.73±0.477	0.30±0.215	0.69±0.394	0.30±0.148		0.55±0.129	0.30±0.143	0.51±0.140	0.25±0.095
LYM	%	76.18±10.136	75.13±9.721	76.58±9.327	77.53±7.858		79.59±4.891	74.70±7.555	79.48±5.646	80.41±5.029
	103/μL	2.95±1.154	1.18±0.381	2.96±0.845	1.51±0.619		3.02±0.785	1.21±0.319	2.88±0.862	1.62±0.780
MONO	%	2.54±1.023	2.24±0.331	2.75±1.113	2.12±0.418		2.43±0.678	2.30±0.849	2.53±0.747	2.24±0.795
EOS	%	2.08±0.968	3.59±1.848	2.25±1.023	3.55±0.871		2.21±0.592	3.59±0.888	2.48±0.684	3.26±1.397
BASO	%	0.11±0.074	0.15±0.118	0.08±0.063	0.07±0.067		0.12±0.063	0.13±0.106	0.13±0.095	0.09±0.057
LUC	%	0.51±0.260	0.15±0.118	0.72±0.394	0.07±0.067		0.65±0.354	0.13±0.106	0.56±0.227	0.09±0.057
No. of animals		10	10	10	10		10	10	10	10

^*: Represents a significant difference at p<0.05 level compared with the vehicle control, ^**: WBC (White blood cell count), RBC (Red blood cell count), HGB (Hemoglobin conc.), HCT (Hematocrit), MCV (Mean corpuscular volume), MCH (Mean corpuscular hemoglobin), MCHC (Mean corpuscular Hb conc.), RDW (Red cell distribution width), HDW (Hb conc. distribution width), PLT (Platelet), MPV (Mean platelet volume), RET (Reticulocyte), ^#: The data shown represent means±S.D. (n=10), %: Control group (G1), Low-dose group (G2: 1,250 mg/10 mL/day), Medium-dose group (G3: 2,500 mg/10 mL/day), High-dose group (G4: 5,000 mg/10 mL/day)